abcam
Contact Us

Overview


Review the similarities and differences between apoptosis and necroptosis, with an introduction to new tools developed to activate effectors of necroptosis.

Necroptosis is a programmed form of necrosis that is dependent on activation of receptor-interacting kinase 3 (RIPK3) and the mixed lineage kinase domain-like (MLKL) psuedokinase. This form of cell death is morphologically distinct from apoptosis, involving membrane rupture and release of cytoplasmic contents.


Topics

  • Apoptosis and necroptosis are functionally linked: enzymes involved in inducing apoptosis, such as caspase-8 and FADD, act to suppress necroptosis
  • New tools to directly activate the necroptotic effectors RIPK3 and MLKL
  • We find that while RIPK1 activates RIPK3 downstream of receptor signaling by using these tools, it is a key suppressor of RIPK3 activation at steady-state


  • Watch now





    Abcam will process your personal data in strict accordance with its privacy policy which can be found here. This will include sending you updates about Abcam, our products, and resources we think would be of interest to you. You can unsubscribe and manage your marketing preferences by clicking the link at the bottom of every email we send. By filling out this form you consent to Abcam sharing your details with your local, authorized distributor for the purpose of answering your query.

    Meet our presenter

    Webinar image

    Meet our presenter

    Dr Andrew Oberst

    Dr Andrew Oberst graduated from Amherst College in 2001. He pursued his graduate studies in Europe, in a collaborative program between the Universities of Rome and Paris, receiving his Doctorate in 2006.

    abcam

    Join with us

    • Linkedin
    • Facebook
    • Twitter
    • Google Plus
    • Terms
    • Privacy policy
    • Legal

    © 1998-2017 Abcam plc. All rights reserved.