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Overview


Review Polycomb group (PcG) proteins and their role in cancer.

Join Professor Bracken as he discusses the connections between Polycombs and cancer, by considering a number of early and more recent studies on the subject, and provides a perspective on the future and how this knowledge could be harnessed for improved cancer therapies.



Topics

  • Introduction: Polycombs are repressors of developmental genes
  • Polycombs initially presumed to be oncogenes: The INK4A and DNA methylation links
  • The NGS revolution: Polycombs are both oncogenes and tumour suppressors
  • Future cancer therapy and perspective


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    Meet our presenter

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    Meet our presenter

    Adrian Bracken

    Adrian Bracken is an Assistant Professor of Medical Molecular Genetics at Trinity College in Dublin, Ireland. Previously, he was a Post-doctoral research fellow in the lab of Professor Kristian Helin at Copenhagen University, Denmark and at the European Institute of Oncology in Milan, Italy.

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