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Overview


Recent studies have revealed that nicotinamide N-methyltransferase (NNMT) is able to regulate mitochondrial energy production, a key pathological feature of Parkinson’s disease.

Join Dr Richard Parsons of Kings College London as he discusses this exciting discovery, including the effect of NNMT expression on Complex I activity and energy production, and the cytotrophic effects of NNMT expression on the neurone.



Topics

  • The mechanics of mitochondrial energy production
  • The function and phenotypic expression of NNMT in the PD population
  • The effect of NNMT expression upon Complex I activity and energy production
  • The various cytotrophic effects of NNMT expression upon the neurone
  • The molecular pathways underlying these


  • Watch now





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    Meet our presenter

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    Meet our presenter

    Dr Richard Parsons

    Dr Richard Parsons gained his PhD in Biochemistry from The University of Birmingham, UK, studying the metabolism of cysteine in the body. He then undertook a post-doctoral position in the laboratory of David Ramsden, University of Birmingham, where he began his research into the expression of NNMT in PD patients. A subsequent move to the laboratory of Anthony Schapira, UCL, UK found him studying Complex I deficiency in PD.

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