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Genetic mutations
Oxidativ
estress
Cleaved
parkin
Toxicity and
neurodegeneration
Cell stress via microglia activation,
resulting in the release of cytokines
REDD-1
mTORC2
Mitochondria
Apoptosis
Decreases expression
of alpha-Synuclein
Cell
survival
Environmental
neurotoxin
Apoptosis
Dopamine
oxidation
Alpha-
synuclein
Lewy body
development
Neurodegeneration
Presynaptic signalling inhibited
Postsynaptic cleft
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Products to help you explore the target of interest in the Parkinson's disease pathway
DJ-1
| Antibody Recombinant Anti-PARK7/DJ1 antibody [EP2815Y] | ab76008 |
|---|---|
| KO cell line Human PARK7 (DJ1) knockout HEK293T cell line | ab266338 |
| KO lysate Human PARK7 (DJ1) knockout HEK293T cell lysate | ab257016 |
| Protein Recombinant Human PARK7/DJ1 protein | ab51198 |
| ELISA Human PARK7 ELISA Kit (DJ1) | ab215535 |
| Antibody Recombinant Alexa Fluor® 488 Anti-PARK7/DJ1 antibody [EP2815Y] | ab203989 |
| Antibody Recombinant Alexa Fluor® 647 Anti-PARK7/DJ1 antibody [EP2815Y] | ab204009 |
| Antibody Recombinant Alexa Fluor® 594 Anti-PARK7/DJ1 antibody [EP2815Y] | ab215102 |
Rab-8A
| Antibody Recombinant Anti-RAB8A antibody [EPR14873] | ab188574 |
|---|---|
| KO cell line Human RAB8A knockout HeLa cell line | ab264993 |
| Protein Recombinant Human RAB8A protein | ab116785 |
| ELISA Human RAB8 ELISA Kit | ab255718 |
| Antibody Recombinant Alexa Fluor® 647 Anti-RAB8A antibody [EPR14873] - C-terminal | ab207548 |
| Antibody Recombinant HRP Anti-RAB8A antibody [EPR14873] - C-terminal | ab209046 |
| Antibody Recombinant PE Anti-RAB8A antibody [EPR14873] - C-terminal | ab210666 |
| Antibody Recombinant Alexa Fluor® 555 Anti-RAB8A antibody [EPR14873] - C-terminal | ab212004 |
| Antibody Recombinant Alexa Fluor® 594 Anti-RAB8A antibody [EPR14873] - C-terminal | ab212006 |
Alpha-synuclein
| Antibody Recombinant Anti-Alpha-synuclein antibody [MJFR1] | ab138501 |
|---|---|
| KO cell line Human RAB10 knockout A549 cell line (ab261868) | ab261868 |
| KO lysate Human SNCA (Alpha-synuclein) knockout HEK293T cell lysate | ab263769 |
| Protein Recombinant human alpha-synuclein protein filament | ab245309 |
| Biochemical NAB 2, alpha-synuclein toxicity protector | ab254489 |
| ELISA Human Alpha-synuclein ELISA Kit | ab260052 |
| Antibody Recombinant Alexa Fluor® 488 Anti-Alpha-synuclein antibody [MJFR1] | ab195025 |
| Antibody Recombinant PE Anti-Alpha-synuclein antibody [MJFR1] | ab209306 |
Misfolding
| Antibody Recombinant Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific | ab209538 |
|---|---|
| Antibody Recombinant Alexa Fluor® 488 Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific | ab216124 |
| Antibody Recombinant Alexa Fluor® 647 Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific | ab216309 |
LRRK2 mutation
| Antibody Recombinant Anti-LRRK2 antibody [MJFF2 (c41-2)] | ab133474 |
|---|---|
| KO cell line Human LRRK2 knockout A549 cell line | ab277993 |
| Protein Recombinant human LRRK2 protein | ab177261 |
| Biochemical MLi-2, LRRK2 inhibitor | ab254528 |
| Antibody Recombinant Alexa Fluor® 647 Anti-LRRK2 antibody [MJFF2 (c41-2)] | ab195023 |
| Antibody Recombinant HRP Anti-LRRK2 antibody [MJFF2 (c41-2)] | ab195024 |
ROS
| Antibody Recombinant Anti-ROS1 antibody [EPMGHR2] | ab189925 |
|---|---|
| Biochemical Diallyl tetrasulfide, ROS inducer (ab143603) / Dihydrorhodamine 123, Fluorescent probe for ROS | ab145260 |
| ELISA DCFDA / H2DCFDA - Cellular ROS Assay Kit | ab113851 |
| Antibody Recombinant Alexa Fluor® 488 Anti-ROS1 antibody [EPMGHR2] | ab225355 |
| Antibody Recombinant Alexa Fluor® 647 Anti-ROS1 antibody [EPMGHR2] | ab225354 |
GSK-3B
| Antibody Recombinant Anti-GSK3 beta antibody [Y174] | ab32391 |
|---|---|
| Protein Recombinant human GSK3 beta protein (Active) | ab60863 |
| Biochemical GSK-3beta Inhibitor VII (4-Bromophenacyl bromide), GSK-3beta inhibitor | ab145937 |
| ELISA Mouse GSK3 beta Antibody Pair - BSA and Azide free | ab243994 |
| Antibody Recombinant Alexa Fluor® 647 Anti-GSK3 beta antibody [Y174] | ab196910 |
| Antibody Recombinant HRP Anti-GSK3 beta antibody [Y174] | ab196911 |
| Antibody Recombinant Alexa Fluor® 488 Anti-GSK3 beta antibody [Y174] | ab197236 |
| Antibody Recombinant Alexa Fluor® 594 Anti-GSK3 beta antibody [Y174] | ab201737 |
| Antibody Recombinant Alexa Fluor® 555 Anti-GSK3 beta antibody [Y174] | ab201738 |
| Antibody Recombinant PE Anti-GSK3 beta antibody [Y174] | ab210619 |
AKT1
| Antibody Recombinant Anti-AKT1 + AKT2 + AKT3 antibody [EPR16798] | ab179463 |
|---|---|
| KO cell line Human AKT1 knockout HeLa cell line | ab264852 |
| KO lysate Human AKT1 knockout HeLa cell lysate | ab256835 |
| Protein Recombinant human AKT1 protein | ab79792 |
| Biochemical SC79, Akt activator | ab146428 |
| ELISA AKT 1/2/3 Total ELISA Kit | ab253298 |
| Antibody Recombinant Alexa Fluor® 488 Anti-AKT1 + AKT2 + AKT3 antibody [EPR16798] | ab200619 |
| Antibody Recombinant PE Anti-AKT1 + AKT2 + AKT3 antibody [EPR16798] | ab210454 |
| Antibody Recombinant Alexa Fluor® 647 Anti-AKT1 + AKT2 + AKT3 antibody [EPR17671] | ab210661 |
| Antibody Recombinant Alexa Fluor® 488 Anti-AKT1 + AKT2 + AKT3 antibody [EPR17671] | ab211402 |
| Antibody Recombinant Alexa Fluor® 594 Anti-AKT1 + AKT2 + AKT3 antibody [EPR17671] | ab217098 |
Mitochondrial dysfunction
| Antibody Anti-Frataxin antibody [18A5DB1] | ab110328 |
|---|---|
| Protein Recombinant Mouse Frataxin protein | ab195175 |
| Biochemical 4-Di-2-ASP, Cationic mitochondrial dye | ab145266 |
| ELISA Human Frataxin ELISA Kit | ab176112 |
| Assay Kit TMRM Assay Kit (Mitochondrial Membrane Potential) | ab228569 |
| Antibody Alexa Fluor® 488 Anti-Frataxin antibody [18A5DB1] | ab156033 |
| Antibody Alexa Fluor® 488 Anti-Frataxin antibody [17A11] | ab197963 |
| Antibody HRP Anti-Frataxin antibody [17A11] | ab197964 |
Apoptosis
| Antibody Recombinant Anti-Annexin V/ANXA5 antibody [EPR3980] | ab108194 |
|---|---|
| KO cell line Apoptosis pathway knockout cell lines panel | ab275493 |
| KO lysate Apoptosis pathway knockout cell lysates panel | ab275045 |
| Protein Recombinant human Annexin V/ANXA5 protein (PE) | ab157016 |
| Biochemical Chloroquine diphosphate, apoptosis and autophagy inhibitor | ab142116 |
| ELISA Human Annexin V ELISA Kit | ab223863 |
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