Necroptosis is a programmed form of necrosis that is dependent on activation of receptor-interacting kinase 3 (RIPK3)1 and the mixed lineage kinase domain-like (MLKL) pseudokinase2. This form of cell death is morphologically distinct from apoptosis, involving membrane rupture and release of cytoplasmic contents.
Learn more about this area with our comprehensive guide.
Our guide includes
Understand the molecular mechanisms of necroptosis, pyroptosis and ferroptosis
Learn to recognize the distinct hallmarks that define non-apoptotic cell death
Tips and tricks
Discover useful tips and tricks to differentiate between non-apoptotic cell death types
Find out what tools are available for your necroptosis research