Find out about:
- Mitochondrial biology and how it relates to mitochondiral toxicity
- The types of assaysa that are used to measure mitochondrial function
- Methods to dig deeper into the mechanisms underlying mitochondrial toxicity
The importance of mitotoxicity
Every year, dozens of pharmaceutical compounds are withdrawn from the market due to adverse effects not discovered during the preclinical or clinical testing. Many of these adverse effects are subtle and do not lead to visible histopathology, but often lead to mitochondrial dysfunction. Therefore, screening for mitochondrial toxicity in the early development stages of a drug is essential.
This in-depth guide outlines how to analyze various aspects of mitochondrial toxicity, and the points you should consider when planning your experiment.