MAPK-ERK pathway

This poster features every step of the MAPK-ERK pathway. You will find Ras activation leading to the MAPK phosphorylation cascade.

You will also find various downstream targets including c-Jun, Fos, and STAT3.

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What is included?

  • MAPK cascade

    Activation of Ras leading to phosphorylation of Raf-1, MEK1/2, and ERK1/2

  • Downstream transcription

    Binding of key transcription factors including c-Jun and Fos 

  • Functions

    Downstream proliferation, differentiation, and growth

  • Alternate routes

    Resulting in apoptosis, cell cycle and inflammatory response