to see productsHomologous recombination
Ionizing radiation
Genotoxic chemicals
Free radicals
Mechanical stress
H2A
y-H2AX
Polyubiquitin
y-H2AX
histones
P
P
P
P
P
P
P
P
ATM
P
ATM
P
Rap80
BRCC36
Abraxas
P
P
Mre11
Rad50
Nbs1
SMC1
Mre11
Rad50
Nbs1
Mdc1
P
P
P
P
Caesin Kinase 2
Rnf8
Ubc13
5'
3'
5'
3'
Rad54
Strand invasion
5'
5'
DNA synthesis
Homologous chromosome
DNA
Pol
DNA
Pol
Ligation and formation
of Holliday Junction
DNA
Ligase1
Holliday
junction
resolvase
Non-crossover
(cut both junctions
vertically or horizontally)
Crossover
(cut both grey or
both blue arrows)
Non-homologous end joining
Ionizing radiation
Genotoxic chemicals
Free radicals
Mechanical stress
ATM
P
ATM
P
Mre11
Rad50
Nbs1
ATM
P
Mre11
Rad50
Nbs1
ATM
P
H4K20me2
y-H2AX
Histones
Histones
Homologous
recombination
P
P
P
P
Strand tethering
53BP1
Ku / Lig4 dependent
pathway
Ku / Lig4 dependent
pathway
Rag 1/2
V
D
J
V
D
J
Hairpin DNA
ends
Ku70
Ku70
Ku80
Ku80
Microhomology
mediated strand
annealing
WRN
WRN
Fen1
PNKP
Flap excision
XRCC1
DNA
Ligase 3
DNA ligation
Short deletion
Inaccurate repair
Polß
XRCC4
DNA
Ligase 4
XLF
No deletion
Accurate repair
Interstrand cross-link repair
FANCM
FAAP24
MHF1
MHF2
ICL
Lesion recognition and
replicative fork convergence
FANCM, FAAP24, MHF1, MHF2 (lesion recognition)
FANCT, FANCL (D2-I ubiquitination)
FANCA, B, C, E, F, G
FAAP20, 100
Replicative helicase eviction
and fork approach at -1 position
CMG
UHRF1
yH2A.X
Replicative helicase
Cdc45
MCM2-7
GINS
P
P
Facnoni
Anemia
Core
Complex
P
CMG
FANC1
ub
P
ub
Translesion synthesis
REV1
or
Polζ
(REV3-REV7)
Homologous Recombination
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Products to help you explore your target of interest in the DNA repair pathway
Rad51 monomers
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