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Autophagy dysregulation
Cyclin-F
TDP-43
Ubiquilin-2
Impaired proteasome
function
TDP-43
KChIp1
Ubiquilin-2
Gene mutations
Increased
oxidative
stress
Ca2+
Mutant SOD1
Impaired
glutamate
reuptake
Glutamate
excitotoxicity
GluR-2
GluR-2
Antibody Recombinant Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR19522] (ab183797)
KO cell line Human GRIA1 knockout SH-SY5Y cell line (ab280788)
Protein Recombinant Human Glutamate Receptor 1 (AMPA subtype) protein (ab112297)
Biochemical NBQX disodium salt, AMPA / kainate antagonist (ab120046)
3Na+
2K+
Pump
dysfunction
Dysfunction
of axonal
transport system
Release of
inflammatory
mediators
Microglia
Inflammation
Microglia
Inflammation
Antibody Recombinant Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064)
KO cell line Human TMEM119 knockout SH-SY5Y cell line (ab280872)
Protein Recombinant Human TMEM119 protein (ab267855)
Biochemical Tuftsin, macrophage activator (ab142730)
Multiplex assay FirePlex Human Discovery Cytokines - Immunoassay Panel 1 (ab243551)
Muscle contacts
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帮助您在肌萎缩性侧索硬化（ALS）交互通路海报中探索目标靶点的产品
SOD1
| Antibody Recombinant Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab51254 |
|---|---|
| KO cell line Human SOD1 knockout MCF7 cell line | ab280781 |
| Protein Recombinant human Superoxide Dismutase 1 protein | ab201408 |
| ELISA Human Superoxide Dismutase 1 ELISA Kit | ab119520 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199453 |
| Antibody Recombinant Alexa Fluor® 488 Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199733 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EPR1726] | ab208369 |
VCP
| Antibody Recombinant Anti-VCP antibody [EPR3307(2)] | ab109240 |
|---|---|
| KO cell line Human VCP knockout A549 cell line | ab280782 |
| Protein Recombinant human VCP protein (Active) | ab269130 |
| Biochemical NMS-873 | ab270807 |
| Antibody Recombinant Alexa Fluor® 488 Anti-VCP antibody [EPR3307(2)] | ab204289 |
| Antibody Recombinant HRP Anti-VCP antibody [EPR3307(2)] | ab204290 |
TARDBP
| Antibody Recombinant Anti-TDP43 antibody [EPR5810] | ab109535 |
|---|---|
| KO cell line Human TARDBP knockout HeLa cell line | ab280783 |
| Protein Recombinant Human TDP43 protein | ab140718 |
| Antibody Recombinant Alexa Fluor® 488 Anti-TDP43 antibody [EPR5810] | ab193842 |
| Antibody Recombinant Alexa Fluor® 594 Anti-TDP43 antibody [EPR5811] | ab208542 |
| Antibody Recombinant Alexa Fluor® 568 Anti-TDP43 antibody [EPR5811] | ab208544 |
| Antibody Recombinant Alexa Fluor® 647 Anti-TDP43 antibody [EPR5811] | ab208623 |
| Antibody Recombinant Alexa Fluor® 488 Anti-TDP43 antibody [EPR18554] | ab237270 |
| Antibody Recombinant Alexa Fluor® 647 Anti-TDP43 antibody [EPR18554] | ab237271 |
| Antibody Recombinant PE Anti-TDP43 antibody [EPR18554] | ab237272 |
NMDA 1
| Antibody Recombinant Anti-NMDAR1 antibody [EPR2481(2)] | ab109182 |
|---|---|
| KO cell line Human GRIN1 (NMDAR1) knockout HeLa cell line | ab264769 |
| Protein Recombinant Human NMDAR2B protein | ab112298 |
| Biochemical D-AP5, NMDA glutamate site antagonist | ab120003 |
| Antibody Recombinant Alexa Fluor® 647 Anti-NMDAR1 antibody [EPR2480Y] | ab225004 |
GluR-2
| Antibody Recombinant Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR19522] | ab183797 |
|---|---|
| KO cell line Human GRIA1 knockout SH-SY5Y cell line | ab280788 |
| Protein Recombinant Human Glutamate Receptor 1 (AMPA subtype) protein | ab112297 |
| Biochemical NBQX disodium salt, AMPA / kainate antagonist | ab120046 |
Astrocytes
| Antibody Recombinant Anti-GFAP antibody [EPR1034Y] | ab68428 |
|---|---|
| KO cell line Human GFAP knockout SK-N-BE(2) cell line | ab280079 |
| Protein Recombinant Human GFAP protein | ab114149 |
| ELISA Human GFAP ELISA Kit | ab223867 |
| ELISA Mouse GFAP ELISA Kit | ab233621 |
| ELISA S100B ELISA Kit | ab234573 |
| Antibody Recombinant Alexa Fluor® 488 Anti-GFAP antibody [EPR1034Y] | ab194324 |
| Antibody Recombinant Alexa Fluor® 647 Anti-GFAP antibody [EPR1034Y] | ab194325 |
| Antibody Recombinant Alexa Fluor® 594 Anti-GFAP antibody [EPR1034Y] | ab201732 |
| Antibody Recombinant Alexa Fluor® 555 Anti-GFAP antibody [EPR1034Y] | ab201735 |
| Antibody Recombinant Alexa Fluor® 568 Anti-GFAP antibody [EPR1034Y] | ab201736 |
| Antibody Recombinant Alexa Fluor® 405 Anti-GFAP antibody [EPR1034Y] | ab206586 |
Microglia inflammation
| Antibody Recombinant Anti-TMEM119 antibody [28-3] - Microglial marker | ab209064 |
|---|---|
| KO cell line Human GSK3B (GSK3 beta) knockout A549 cell line | ab277904 |
| KO cell line Human TMEM119 knockout SH-SY5Y cell line | ab280872 |
| Protein Recombinant Human TMEM119 protein | ab267855 |
| Biochemical Tuftsin, macrophage activator | ab142730 |
| Multiplex assay FirePlex Human Discovery Cytokines - Immunoassay Panel 1 | ab243551 |
| Multiplex assay FirePlex Mouse Discovery Cytokines - Immunoassay Panel | ab243554 |
| Multiplex assay FirePlex Human Key Cytokines - Immunoassay Panel | ab243549 |
| Multiplex assay FirePlex Mouse Key Cytokines - Immunoassay Panel | ab235656 |
| Multiplex assay FirePlex Rat Key Cytokines - Immunoassay Panel | ab235662 |
| Antibody Recombinant Alexa Fluor® 647 Anti-TMEM119 antibody [106-6] | ab225494 |
| Antibody Recombinant PE Anti-TMEM119 antibody [106-6] | ab225496 |
| Antibody Recombinant Alexa Fluor® 488 Anti-TMEM119 antibody [106-6] | ab225497 |
Lysosome
| Antibody Recombinant Anti-LAMP1 antibody [EPR21026] | ab208943 |
|---|---|
| KO cell line Human LAMP1 knockout U-87 MG cell line | ab280794 |
| Protein Recombinant Human LAMP1 protein | ab151863 |
| ELISA Human LAMP1 ELISA Kit | ab277464 |
| ELISA Human LAMP2 ELISA Kit | ab277449 |
| Antibody Recombinant Alexa Fluor® 647 Anti-LAMP1 antibody [EPR21026] | ab237307 |
hSod1
| Antibody Recombinant Anti-Annexin V/ANXA5 antibody [EPR3980] | ab108194 |
|---|---|
| KO cell line Human SOD1 knockout MCF7 cell line | ab280781 |
| Protein Recombinant human Superoxide Dismutase 1 protein | ab201408 |
| ELISA Human Superoxide Dismutase 1 ELISA Kit | ab119520 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199453 |
| Antibody Recombinant Alexa Fluor® 488 Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199733 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EPR1726] | ab208369 |
SOD1 aggregates
| Antibody Recombinant Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab51254 |
|---|---|
| KO cell line Human SOD1 knockout MCF7 cell line | ab280781 |
| Protein Recombinant human Superoxide Dismutase 1 protein | ab201408 |
| ELISA Human Superoxide Dismutase 1 ELISA Kit | ab119520 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199453 |
| Antibody Recombinant Alexa Fluor® 488 Anti-Superoxide Dismutase 1 antibody [EP1727Y] | ab199733 |
| Antibody Recombinant HRP Anti-Superoxide Dismutase 1 antibody [EPR1726] | ab208369 |