Download your interactive pathway for amyotrophic lateral sclerosis:

Get to the root of amyotrophic lateral sclerosis (ALS) with our interactive poster detailing genes and molecular pathways involved in disease development.

ALS is a neurodegenerative disorder characterized by a progressive loss of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. Our interactive poster will help you to find the best tools to study the key factors in the development of ALS.

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Track key genes and molecular mechanisms involved in ALS:

Genetic mutations

Find out the role of mutations in DNA/RNA-regulating genes, such as C9orf72, SOD1, FUS, TARDBP, in ALS pathogenesis

Impaired proteasome function

Study the role of proteasome impairment in ALS

Autophagy dysregulation

Explore how autophagy dysregulation leads to the development of ALS

Glutamate-mediated excitotoxicity

Investigate the role of glutamate excitotoxicity in the ALS pathogenesis